Effects of the butanolic, methanolic, petroleum ether and aqueous extracts of the roots of Eranthemum roseum on the glucose and lipid profile were investigated in alloxan induced diabetic rats. Butanolic extract showed a significant reduction (P<0.01) in blood glucose and serum lipid profile in alloxan induced diabetes and also lowered the blood glucose (P<0.01) in oral glucose tolerance test at a dose of 250mg/kg bw p.o. Glibenclamide at the dose of 5mg/kg was used as standard drug. In vitro screening of the extracts for antioxidant activity using DPPH, TBARS and reducing power assay showed that the butanolic extract exhibited potent free radical scavenging and lipid peroxidation inhibitory effects as compared with other extracts. The phytochemical investigation showed that the roots contain steroidal saponin glycosides. The results suggest that the butanolic fraction had good antihyperglycemic, antioxidant and hypolipidemic activities, which can be attributed to its saponin content.
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